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AICAR (chemical name: 5-Aminoimidazole-4-carboxamide
ribonucleotide) is a peptide, which is an intermediate within the
generation of inosine monophosphate and directly related to
metabolic regulation. The most important mechanism that AICAR is
known for is its ability to block enzymes both in intracellular and
extracellular levels, which, in turn, allows for an accelerated
stimulation of glucose uptake and increase protein kinases in
skeletal muscle tissue. These two functions allow for more energy
conversion, which helps burn fat and also sustain output in
activity. This is what scientists and athletes/bodybuilders are
interested in, but there are some amazing side effects.
Interestingly, AICAR has been shown to protect against ischemic
injury. This type of injury is directly related to the restriction
of blood to tissues, which can cause insufficient amounts of oxygen
and glucose needed to keep the tissue alive. This can lead to
thrombosis, embolisms, and vasoconstriction. AICAR can be used as a
stabilizing peptide for ischemic episodes, and it can allow for
proper blood flow to the myocardium (heart). This function is very
interesting, as AICAR could be fundamentally used to treat the
heart muscle in the aftermath of a heart attack. This might reduce
the possibility for ischemic injuries. Abnormal growths of heart
tissues and heart valve function have also been altered in animal
studies that used the peptide AICAR, which is a downside.
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of
cardiovascular diseases.acts by entering nucleoside pools,
significantly increasing levels of
adenosine during periods of ATP breakdown
AICAR (AICA-Riboside) strongly inhibits the transcription of
PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte
studies it has been shown to antagonize lipolysis induced by
isoprenaline and has been suggested for use in kinase cascade
research. Additionally, research indicates that AICAR blocks the
differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate
that AICAR can mimic the activity of insulin (sc-211647) by
activating AMPK (AMP-activated protein kinase), and affecting the
expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase).
The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the
monophosphorylated derivative of AICA-Riboside, and it can serve as
the substrate for the aminoimidazole carboxamide ribonucleotide
transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR
is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.
Dosage and Usage
Here is where AICAR becomes a pipe dream for anyone who is not a
top level endurance athlete or bodybuilder. The dosages recommended
to achieve the benefits from this peptide are insanely high. AICAR
must be dosed at around 500mgs per kilogram (kg) of body weight. A
gram of real pure AICAR can cost $100 USD or more, so single
dosages for humans could be well in to the several hundreds of
dollars! Some say that this can be circumvented by stacking it with
Cardarine (GW), but you still need to spend a lot of money for
perhaps little to no result if you are not dosing high enough
Yes, the peptide AICAR has amazing properties, some which even show
the slowing of growth in cancer cells, but for the average athlete
this has no basis in a day to day regiment. On the other hand,
Cardarine (GW) has been shown to provide users with more than
enough results as an Activated Receptor d agonists (PPARd) and it's
cost-effective for everyone.
The most concerning side effects from AICAR are the direct effects
it has on your heart. It can cause enlarged growth in cardiac
tissue, and it can effect blood flow. In turn, this could affect
the flow of blood to a person's brain. In addition, it has been
noted that defects of heart valves may also be caused by the
peptide AICAR. The heart is the most important muscle in the entire
body, and the last thing anyone wants to do is treat it badly.
Anecdotally, some logs indicated extreme loose bowls, dry mouth,
and lack of hunger.
Possible enlarged growth of heart
Possible defects to the heart valve
Problems with blood flow
Problems with blood and nutrient transfer to the brain
Problems with bowls
For the cost and the potential side effects, the peptide AICAR has
no real use in the sports or bodybuilding world. It is touted as
exercise in a bottle, but most athletes don't want to sit around
and do nothing, they actually enjoy being active and staying fit.
This is why Cardarine is by far the more superior PPARd, as it is
activated by exercise and has many of the same benefits that AICAR
does without the extremely nasty side effects. Unless you are a
professional endurance athlete with extra money to spend and need
the very small edge over competition, there is very little reason
to use AICAR
Over 15years specialized in this field,Professional &
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1. Best prices with High quality.
2. Rich experienced in delivering the parcels to you.
3. Enough stock ensure the prompt delivery time.
4. Good after-sales service.
5. Specials are possible when the order is big enough.
How to proceed an order:
1st: Please let me know what you need-Which product/Cas No.
quantity, and the destination country.
2nd: You send us the purchase order once we cme to an agreement on
3rd: Parcel would be delivered upon full payment received.
4th: Express Tracking No.will be provided about the parcels.
5th: You will get the parcels in 7days.
6th: After-sales service would be provided after you receive
Min. order quantity: 10g
Payment Term: T/T , Moneygram , Western Union.
Shipping way: EMS, DHL, Fedex, UPS....
Delivery:Within 3working days after received payment .and, Express
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